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The Magic Mix for Joint Pain? Try Synergistic Therapies

Reviewed by Kristen Reynolds, MD of Forum Health Mequon and Brookfield


If you’re dealing with joint pain and have tried everything to find relief, this is for you. We like to call our combination treatment for joint pain the “magic mix” or the “secret sauce.” 


Whatever you call it, combinations of certain enzymes, treatments, and supplements can work synergistically to help enhance your healing and recovery. For instance, ozone therapy combined with the BEMER PEMF (pulsed electromagnetic fields) system works wonders for complex musculoskeletal conditions such as Achilles tendonitis, arthritis, and chronic pain. This dynamic duo helps to reduce inflammation, improve blood flow, and promote tissue repair, offering significant relief for those struggling with these conditions. 

The Power of Systemic Proteolytic Enzymes and Collagen

Recently, our integrative and functional medicine experts have been fascinated by the combination of systemic proteolytic enzymes and collagen for joint health.  


Systemic proteolytic enzymes play a crucial role in digestion, immune function, and inflammation reduction. Enzyme therapies can break up immune complexes, known as inflammatory mediators. In a six-week study of 42 rheumatoid arthritis patients, systemic proteolytic enzymes led to clinical improvement and reduced circulating immune complexes in over 60% of patients indicating their potent anti-inflammatory effects. 


Collagen, on the other hand, is a protein fundamental to the structure of many parts of the body, including skin, bones, muscles, tendons, and ligaments. It’s often referred to as the “glue” that holds these structures together. Supplementing with collagen helps replenish the body’s natural collagen reserves, promoting tissue repair and reducing joint pain.  


Together, these two therapies work to break down harmful protein complexes and heal joint tissues, providing comprehensive support for conditions like arthritis and tendonitis. 


Our Favorites: 


  1. Vascuzyme by Ortho Molecular: This supplement contains a powerful blend of protease, amylase, papain, trypsin, lipase, chymotrypsin, and bromelain, along with quercetin and rutin, which are well-known flavonoids. 

    Vascuzyme is excellent for reducing inflammation, supporting musculoskeletal health, and enhancing exercise recovery. These enzymes help break down inflammatory complexes, alleviating joint pain and promoting healing.

  2. CollaGEN by Ortho Molecular: This supplement supports joints, including cartilage, tendons, and ligaments. Collagen hydrolysate, a key ingredient, has been shown in a 2018 systematic review and meta-analysis to have a significant and clinically important effect on pain reduction. 

    Systematic reviews and meta-analyses are considered some of the highest levels of evidence in medicine, underscoring the efficacy of collagen for joint health. 

Contraindications to Proteolytic Enzymes

It’s important to note that proteolytic enzymes are not suitable for everyone. Contraindications may include: 

  • Prescription blood thinners 
  • Surgery within the last two weeks 
  • Stomach ulcers 
  • Pregnancy/lactation 
  • Current antibiotic use 
  • Allergies to pineapple or papaya (due to bromelain content) 

Start Healing Today

By combining these powerful therapies, you can harness the synergistic benefits of systemic proteolytic enzymes and collagen to support joint health and overall wellness. Always consult with a healthcare provider before starting any new supplement regimen, especially if you have underlying health conditions or are taking other medications. 


Need expert guidance on managing your joint pain? Reach out to us and schedule a health advisor call today!